High success rate of nocturnal enuresis treatment during the stay-home period for COVID-19.

Abstract

ObjectivesTo clarify whether enuresis treatment was more effective during the stay‐home period for the coronavirus disease 2019 pandemic, when restrictions on activities enabled patients to concentrate on treatment.MethodsWe performed a retrospective, nonrandomized cohort study for monosymptomatic enuresis during the coronavirus disease 2019 pandemic (March–June 2020) and a 2‐year comparator period (March–June 2018 and March–June 2019). Primary outcome was treatment response, defined as a change in the number of wet nights per week within 6 months following enrollment. The time‐dependent occurrence of treatment response was evaluated with the Kaplan–Meier method and the log‐rank test. The Cox proportional hazards regression model was used to identify risk factors for treatment response. The range of appropriate sample sizes for this primary outcome was 39–48.ResultsOf our 41 enrolled patients, 28 (68%) were male and mean age was 8.8 years. The complete response rate was 73% during the coronavirus disease 2019 pandemic period and 27% during the comparator period. Log‐rank tests showed a higher cumulative incidence of complete response in the pandemic period (P = 0.020). Cox regression analysis identified treatment during the coronavirus disease 2019 pandemic (hazard ratio 2.533; 95% confidence interval 1.069–6.006) and dinner before 19:00 (hazard ratio 4.184; 95% confidence interval 1.56–11.252) as significantly associated with treatment response.ConclusionsThe rate of enuresis treatment response was uncommonly high during the stay‐home period for the coronavirus disease 2019 pandemic. Restrictions on daily life may provide opportunities to concentrate on treatments for chronic illnesses, leading to more success.