High-Strength Metal Nanomagnets for Diagnostics and Medicine: Carbon Shells Allow Long-Term Stability and Reliable Linker Chemistry

Abstract

The rapidly growing applications of nanomagnets in magnetic drug delivery and separation in clinical diagnostics require strong and reliable magnetic vehicles. Strength conveys rapid processing, high delivery/targeting yield and rapid results when used in clinics. Reliability enables recycling of nanomagnets, regulatory-conforming drug formulations and efficient use of (expensive) antibodies in diagnostics, combined with reduced leaching (reagent loss). The present work illustrates how metal-based nanomagnets provide a two-three-times stronger magnetic particle than conventional magnetite-based materials. Ligands, antibodies or drugs can be anchored to such carbon/metal core/shell nanomagnets over covalent, hydrolysis-resistant carbon-carbon bonds. This linker chemistry resists strong acids, sterilization and prolonged storage or aggressive treatment. As dispersions, functional nanomagnets rapidly scan liquids/tissue by Brownian diffusion, capture/deliver/react at a target and are efficiently recollected after use. Metal iron-based, carbon-coated nanomagnets consist of particularly well-accepted materials and now open stable nanomagnets to a broad range of fascinating separation problems in biomedical research.