High stereoselectivity synthesis of Z-3-methyleneisoindolin-1-ones on a Cu/ETS-10 catalyst via domino coupling–cyclization without the use of protective groups and ligands

Abstract

Using Cu/ETS-10 to synthesize Z-3-methyleneisoindolin-1-ones through coupling–cyclization of 2-halobenzamides with aromatic alkynes in the absence of protected 2-halobenzamides and ligands.