Abstract
A highly stereoselective lithium-bromine exchange reaction of 2-trifluoromethyl-3,3-dibromoallylic alcohols is described. (E)- and (Z)-2-trifluoro-3-bromoallylic alcohols were obtained in THF and hexane, respectively. The lithium carbenoid intermediate was stable even at -40 degrees C and could be trapped by various electrophiles to afford functionalized 2-trifluoromethyl-3-bromoallylic alcohols. [reaction: see text]
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