Abstract
We previously described a fiber based Doppler optical coherence tomography system [1] capable of imaging embryo cardiac blood flow at 4~16 frames per second with wide velocity dynamic range [2]. Coupling this system to a linear scanning fiber optical catheter design that minimizes friction and vibrations, we report here the initial results of in vivo endoscopic Doppler optical coherence tomography (EDOCT) imaging in normal rat and human esophagus. Microvascular flow in blood vessels less than 100 microm diameter was detected using a combination of color-Doppler and velocity variance imaging modes, during clinical endoscopy using a mobile EDOCT system.
Highlights
Optical coherence tomography (OCT) [3] imaging of the gastrointestinal (GI) tract has been demonstrated by several groups using radial [4,5], lateral [6], or linear scanning catheter probes [7] to visualize subsurface tissue microstructure during endoscopy
We previously described a fiber based Doppler optical coherence tomography system [1] capable of imaging embryo cardiac blood flow at 4~16 frames per second with wide velocity dynamic range [2]
Coupling this system to a linear scanning fiber optical catheter design that minimizes friction and vibrations, we report here the initial results of in vivo endoscopic Doppler optical coherence tomography (EDOCT) imaging in normal rat and human esophagus
Summary
Optical coherence tomography (OCT) [3] imaging of the gastrointestinal (GI) tract has been demonstrated by several groups using radial [4,5], lateral [6], or linear scanning catheter probes [7] to visualize subsurface tissue microstructure during endoscopy. An initial clinical study [8] suggested that rule-based criteria derived from the microstructural images might be useful for diagnosis of preneoplastic lesions in the human GI tract. Its scan geometry and velocity sensitivity (1−2 mm/s) made it more suitable for imaging in lumens with small diameter and high flow rate, such as the coronary artery. Larger diameter organs such as the GI tract are probably more accessible with the linear scanning catheter [7]. Adding Doppler capability to endoscopic OCT may allow detection of the vasculature associated with cancer or other pathological conditions, as well as monitoring of treatments that target the vasculature
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