High-Speed TOFMS Detection for Capillary Electrophoresis

Abstract

A new, high-speed data acquisition system was tested for high storage rate time-of-flight mass spectrometry (TOFMS) detection in capillary electrophoresis (CE). For high spectral acquisition rates of 4 kHz, a spectral storage rate of 80 spectra s(-)(1) was achieved. The resulting detection limit was in the low amol range (10-25 amol) for continuous infusion investigations.