Abstract

Flow/hyperlayer field-flow fractionation (FFF) has been successfully applied to the rapid size-based fractionation and characterization of various 3-μm and 5-μm commercial high-performance liquid chromatography silica supports. Because highj-resolution information on both average particle diameter and size distribution was obtained in less than 3 min by using a relatively simple apparatus, the method is attractive for the routine characterization of chromatographic packing material. Flow/hyperlayer FFF is not only faster than most sedimentation methods, it is ideally suited for the characterization of porous particles since separation is based solely on diameter and is independent of density.

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