Abstract
BackgroundCine cardiovascular magnetic resonance (CMR) is challenging in patients who cannot perform repeated breath holds. Real-time, free-breathing acquisition is an alternative, but image quality is typically inferior. There is a clinical need for techniques that achieve similar image quality to the segmented cine using a free breathing acquisition. Previously, high quality retrospectively gated cine images have been reconstructed from real-time acquisitions using parallel imaging and motion correction. These methods had limited clinical applicability due to lengthy acquisitions and volumetric measurements obtained with such methods have not previously been evaluated systematically.MethodsThis study introduces a new retrospective reconstruction scheme for real-time cine imaging which aims to shorten the required acquisition. A real-time acquisition of 16-20s per acquired slice was inputted into a retrospective cine reconstruction algorithm, which employed non-rigid registration to remove respiratory motion and SPIRiT non-linear reconstruction with temporal regularization to fill in missing data. The algorithm was used to reconstruct cine loops with high spatial (1.3-1.8 × 1.8-2.1 mm2) and temporal resolution (retrospectively gated, 30 cardiac phases, temporal resolution 34.3 ± 9.1 ms). Validation was performed in 15 healthy volunteers using two different acquisition resolutions (256 × 144/192 × 128 matrix sizes). For each subject, 9 to 12 short axis and 3 long axis slices were imaged with both segmented and real-time acquisitions. The retrospectively reconstructed real-time cine images were compared to a traditional segmented breath-held acquisition in terms of image quality scores. Image quality scoring was performed by two experts using a scale between 1 and 5 (poor to good). For every subject, LAX and three SAX slices were selected and reviewed in the random order. The reviewers were blinded to the reconstruction approach and acquisition protocols and scores were given to segmented and retrospective cine series. Volumetric measurements of cardiac function were also compared by manually tracing the myocardium for segmented and retrospective cines.ResultsMean image quality scores were similar for short axis and long axis views for both tested resolutions. Short axis scores were 4.52/4.31 (high/low matrix sizes) for breath-hold vs. 4.54/4.56 for real-time (paired t-test, P = 0.756/0.011). Long axis scores were 4.09/4.37 vs. 3.99/4.29 (P = 0.475/0.463). Mean ejection fraction was 60.8/61.4 for breath-held acquisitions vs. 60.3/60.3 for real-time acquisitions (P = 0.439/0.093). No significant differences were seen in end-diastolic volume (P = 0.460/0.268) but there was a trend towards a small overestimation of end-systolic volume of 2.0/2.5 ml, which did not reach statistical significance (P = 0.052/0.083).ConclusionsReal-time free breathing CMR can be used to obtain high quality retrospectively gated cine images in 16-20s per slice. Volumetric measurements and image quality scores were similar in images from breath-held segmented and free breathing, real-time acquisitions. Further speedup of image reconstruction is still needed.
Highlights
Cine cardiovascular magnetic resonance (CMR) is challenging in patients who cannot perform repeated breath holds
The acquired raw real-time images were reconstructed with low temporal resolution and high spatial resolution. e) An image-based respiratory signal was computed from the real-time cine images, as previously proposed in [15] where the prominent respiratory motion direction is adapted to the slice orientation
A reconstruction with fair image quality may be achieved for some slices, it was found to lack the robustness afforded by the non-linear reconstruction
Summary
Cine cardiovascular magnetic resonance (CMR) is challenging in patients who cannot perform repeated breath holds. High quality retrospectively gated cine images have been reconstructed from real-time acquisitions using parallel imaging and motion correction These methods had limited clinical applicability due to lengthy acquisitions and volumetric measurements obtained with such methods have not previously been evaluated systematically. The available clinical techniques rely on breath-held, segmented acquisitions to fill the k-space over multiple heartbeats using retrospective ECG gating. With this approach only one or two slices are acquired per breath-hold requiring multiple breath-holds to cover the ventricles for functional evaluation. This strategy is reliable in many clinical patients, it leads to a lengthy exam. Even in patients who can hold their breath at the beginning of the study, they often fail to maintain consistent breath-hold compliance throughout the study
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