Abstract
Background Signal regulatory protein alpha (SIRPA) is an inhibitory receptor expressed in macrophages and a potential therapeutic target in cancers. This study aims to investigate the functional role of SIRPA in esophageal carcinoma (ESCA). Methods Based on the Oncomine and The Cancer Genome Atlas (TCGA) database, SIRPA expression and clinical value were determined. Gene set enrichment analysis (GSEA) was performed to predict the mechanism underlying the oncogene role of SIRPA. Spearman's correlation analysis was used to analyze the effects of SIRPA on the molecular relationship and immune landscape. Results SIRPA was highly expressed across Oncomine and TCGA databases and correlated with poor overall survival and disease-specific survival. There was an expression difference among clinical characteristics. Functional annotation showed that cancer-related biological function and pathways were enriched in the high SIRPA expression group. Besides, SIRPA strongly and extensively affected the immune infiltrates. Conclusion SIRPA might be an oncogene and a target of immunotherapy in ESCA.
Highlights
Esophageal carcinoma (ESCA) is the eighth most common malignant and the sixth most deadly tumor in the world [1].It is one of the common malignant tumors of the digestive tract in China, with the main histological types being squamous carcinoma and adenocarcinoma [2]
From the Oncomine database, we found that Signal regulatory protein alpha (SIRPA) was highly expressed in esophageal carcinoma (ESCA) (Figure 1(a) and Table 1)
Through integrating the Oncomine and e Cancer Genome Atlas (TCGA) and GTEx database, we observed the overexpression of SIRPA again (Figure 1(b))
Summary
Esophageal carcinoma (ESCA) is the eighth most common malignant and the sixth most deadly tumor in the world [1]. It is one of the common malignant tumors of the digestive tract in China, with the main histological types being squamous carcinoma and adenocarcinoma [2]. Research on radiotherapy and targeted therapy for ESCA has been carried out, and some patients have benefited from the integrated treatment [5]. Active clinical research to identify effective targets and develop effective drugs to control tumor cell infiltration and metastasis is the key to improving the prognosis of ESCA patients. This study aims to investigate the functional role of SIRPA in esophageal carcinoma (ESCA)
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