Abstract
Background: Surgical outcomes in hepatocellular carcinoma (HCC) patients with high-signal-intensity in the hepatobiliary (HB) phase of gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) have not been evaluated in detail. Methods: Between 2008 and 2013, 21 HCC patients showed high-signal-intensity in the HB phase and underwent curative hepatectomy at five medical university hospitals. Surgical outcomes were compared among the 21 patients with high-signal-intensity HCC and 194 patients with low-signal-intensity HCC. Results: After propensity score matched analysis, the Child-Pugh class A did not differ between 21 patients with high-signal-intensity HCC and 21 patients with low-signal-intensity HCC, nor did the size of HCC or the number of HCCs. The 5-year survival rate was significantly higher in patients with high-signal-intensity HCC (83%) than in patients with low-signal-intensity HCC (61%, p = 0.0177). The 5-year recurrence-free survival rate was significantly higher in patients with high-signal-intensity HCC (54%) than in patients with low-signal-intensity HCC (39%, p = 0.047). Multivariate analysis showed high-signal-intensity HCC to be a significant independent prognostic factor for survival and recurrence-free survival in HCC. Conclusions: High-signal-intensity in the HB phase is a novel prognostic factor for favorable surgical outcomes in patients with HCC.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
