Abstract
Aims: This study aims to access the predicting value of serum uric acid (UA) and high-sensitivity C reactive protein (hs-CRP) concentration on three-year cardiovascular-related mortality in patients performing continuous ambulatory peritoneal dialysis (CAPD).Methods: A total of267 CAPD patients [150 male (56.2%); mean age 48.93 ± 13.58 years] were included in our study. All patients had measured serum UA and hs-CRP concentration. A high-sensitivity particle-enhanced immunoturbidimetric assay determined serum hs-CRP; serum UA levels were determined using an enzymatic colorimetric assay. All patients were followed for three years to detect cardiovascular-related mortality by cardiologists and stroke specialists.Results: Mean serum UA level was 415.16 ± 84.28 µmol/L, 58.4% of patients had increased serum UA level. Median serum hs-CRP level was 2 (1-4) mg/L, 12.4% of patients had increased serum hs-CRP level. During 36 months of follow-up, 41 patients (15.4%) had cardiovascular-related mortality. The results of Cox proportional hazards regression showed that hypertension, diabetes, high serum UA and hs-CRP were risk factors that related to cardiovascular-related mortality (p<0.05). The receiver operating characteristic (ROC) curve and Kaplan-Meier analysis results showed that UA and hs-CRP level had predictive value for three-year cardiovascular-related mortality in CAPD patients [uric acid: area under the curve (AUC)=0.822; hs-CRP: AUC=0.834, p < 0.001].Conclusion: High serum UA and hs-CRP levels were predictive factors of cardiovascular-related mortality in CAPD patients.
Highlights
Peritoneal dialysis (PD) is one of the most common kidney replacement therapies
The results of Cox proportional hazards regression showed that hypertension, diabetes, high serum uric acid (UA) and high-sensitivity C reactive protein (hs-C-reactive protein (CRP)) were risk factors that related to cardiovascular-related mortality (p
The receiver operating characteristic (ROC) curve and Kaplan-Meier analysis results showed that UA and hs-CRP level had predictive value for threeyear cardiovascular-related mortality in continuous ambulatory peritoneal dialysis (CAPD) patients [uric acid: area under the curve (AUC)=0.822; hsCRP: AUC=0.834, p < 0.001]
Summary
Peritoneal dialysis (PD) is one of the most common kidney replacement therapies. Peritoneal dialysis is performed by using a catheter to infuse sterile solution into the peritoneal cavity. The peritoneum is used as an exchange filter to remove solutes [1,2,3]. PD consists of two methods: continuous ambulatory and automated PD, in which continuous ambulatory PD (CAPD) is widely used in Vietnam. A mortality rate in CAPD from 8.3% to 39.2% was reported in previous studies [4,5,6]. Prolonged use of CAPD is related to a higher mortality rate [4,6], in which mortality due to cardiovascular events was behind infection-related ones
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