Abstract
BackgroundHypertension is a risk factor for peripheral arterial disease (PAD). Subjects with PAD are at increased risk of future cardiovascular (CV) events. Resistin is involved in the pathological processes of CV diseases. The aim of this study is to investigate whether resistin level is correlated with PAD in hypertensive patients.MethodsOne hundred and twenty-four hypertensive patients were enrolled in this study. Ankle-brachial index (ABI) values were measured using the automated oscillometric method. An ABI value < 0.9 defined the low ABI group. Anthropometric analysis with waist circumference and body mass index, and fasting serum levels of blood urea nitrogen, creatinine, glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total calcium, phosphorus, and high-sensitivity C-reactive protein (hs-CRP) were measured using standard enzymatic automated methods. Serum levels of human resistin were determined using a commercially available enzyme immunoassay.ResultsEighteen hypertensive patients (14.5%) were included in the low ABI group. Hypertensive patients in the low ABI group were older (p = 0.043) and had higher serum creatinine (p < 0.001), high-sensitivity C-reactive protein (hs-CRP; p = 0.013), and resistin (p < 0.001) levels but a lower estimated glomerular filtration rate (p = 0.002) than patients in the normal ABI group. After the adjustment for factors that were significantly associated with PAD on multivariate logistic regression analysis, serum resistin (odds ratio [OR], 1.176; 95% confidence interval [CI], 1.028–1.345; p = 0.018) was also an independent predictor of PAD in hypertensive patients.ConclusionsA high serum resistin level is an independent predictor of PAD in hypertensive patients.
Highlights
Hypertension is a risk factor for peripheral arterial disease (PAD)
PAD has been known to increase the risk of CV morbidity and mortality, resistin is involved in the pathological processes of CV diseases, and hypertension is one of the risk factors of
Adjustment of the factors significantly associated with PAD on multivariate logistic regression analysis revealed that increased serum resistin level was an independent predictor of PAD in hypertensive patients (Table 4); plotting of the receiver operating curve (ROC) curve for PAD prediction revealed that the area under the curve (AUC) for resistin was 0.870 (Fig. 1)
Summary
Hypertension is a risk factor for peripheral arterial disease (PAD). Resistin is involved in the pathological processes of CV diseases. The aim of this study is to investigate whether resistin level is correlated with PAD in hypertensive patients. PAD is associated with an increased risk of incident coronary and cerebrovascular disease morbidity and mortality [2, 3]. Serum resistin levels were higher in PAD patients than in healthy controls and an independent risk factor of PAD in a Chinese study [7]. PAD has been known to increase the risk of CV morbidity and mortality, resistin is involved in the pathological processes of CV diseases, and hypertension is one of the risk factors of
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