Abstract
BackgroundHigh 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals.ObjectiveInvestigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent.MethodsProspectively drawn blood samples from individuals later developing relapsing–remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry.ResultsHigh levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50–0.93).ConclusionThese findings further support a role for vitamin D in MS aetiology.
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