High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome

Tohru Funahashi,Yasuhiko Nakagawa,Iichiro Shimomura,Ken Kishida,Toru Mazaki,Koji Yanagi,Hironori Kobayashi,Hiroyoshi Yokoi

doi:10.1186/1475-2840-13-9

Tohru Funahashi, Yasuhiko Nakagawa

Open Access

https://doi.org/10.1186/1475-2840-13-9

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Abstract

BackgroundThe complement system is part of the immune system in acute coronary syndrome (ACS). Adiponectin has anti-atherogenic and anti-inflammatory properties. Adiponectin and C1q form a protein complex in blood, and serum C1q binding adiponectin (C1q-APN) can be measured. We investigated the comparative evaluation of serum C1q-APN levels in males with ACS, stable angina pectoris (SAP) versus controls.MethodsThe study subjects were 138 Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays. Patients were divided into three groups according to the clinical condition: ACS (n = 78), SAP (n = 41) or normal coronary (NC, n = 19) groups.ResultsSerum C1q levels were significantly higher in the ACS group (54.9±1.2 μg/mL) than in the NC group (48.0±2.5 μg/mL). Although serum Total-APN levels were significantly lower in the SAP and ACS groups, compared with the NC group (7.0±0.5, 7.2±0.3, 10.6±2.0 μg/mL, respectively), serum C1q-APN levels were significantly higher in the ACS group than in the NC and SAP groups (112.1±4.1, 66.3±4.4, 65.7±2.9 units/mL, respectively).ConclusionsPatients with ACS had higher serum C1q-APN levels.Trial RegistrationUMIN000002997

Highlights

The complement system is part of the immune system in acute coronary syndrome (ACS)
There were no significant differences in age, body mass index (BMI), Visceral fat area (VFA) and subcutaneous fat area (SFA) between the three groups, which is known to influence serum levels of TotalAPN [2] and C1q binding adiponectin (C1q-APN) [17]
Serum high-molecular weight-adiponectin (HMW-APN) levels were significantly lower in the stable angina pectoris (SAP) group (4.1±0.5 μg/mL) and trended to be lower in ACS group (4.9±0.4), compared with the normal coronary group (NC) group (6.8±1.6, Figure 1b)

Summary

Introduction

The complement system is part of the immune system in acute coronary syndrome (ACS). Adiponectin has anti-atherogenic and anti-inflammatory properties. We investigated the comparative evaluation of serum C1q-APN levels in males with ACS, stable angina pectoris (SAP) versus controls. Disruption of atherosclerotic plaques with associated thrombus is responsible for the majority of the acute coronary syndrome (ACS). Adiponectin, an adipocyte-derived blood protein [2] is present abundantly in injured arteries [3,4] and has antiinflammatory, anti- atherosclerotic properties [5,6] and anti-diabetic property [7,8]. Low levels of total-adiponectin (Total-APN) have been reported in patients with coronary artery disease (CAD), including angina and ACS [9,10,11,12,13,14,15]. The aim of the present study was to clarify the comparative evaluation of serum C1q-APN levels in males with ACS, stable angina pectoris (SAP) versus controls

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