High Serum Bisphenol-A Level Might Increase the Risk of Young Intracerebral Hemorrhage

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Background and Purpose: Bisphenol-A (BP-A) is a widespread industrial chemical used in the synthesis of polycarbonate plastics and epoxy resins. Recent epidemiological investigations have disclosed the associations between BP-A exposure and some diseases. Evidence from experimental animal studies and clinical studies suggests the BP-A can act as an estrogenic endocrine disruptor and impact neurological outcome. The present study aimed to determine serum BP-A concentrations in youth patients with unexplained intracerebral hemorrhage (YUICH) as well as the relationship and the change among serum BP-A levels, thyroid function parameters, thyroid autoimmunity, and insulin-like growth factor-1 (IGF-1) compared to a control group. Methods: Three hundred and sixty-five YUICH patients and three hundred-eighty age and gender-matched healthy controls were included from the Affiliated Changzhi Municipal people's Hospital of Shanxi Medical University and the Affiliated Heping Hospital of Changzhi Medical college. Serum BP-A levels and insulin growth factor-1 (IGF-1) were measured using corresponding ELISA kits. Several hormonal parameters, including: free and total thyroxine (FT4, TT4), or free and total triiodothyronine (FT3, TT3), thyroid stimulating hormone (TSH), antithyrogobulin (TgAb), antithyroperoxidase (TPOAb), and antithyrotrophin receptor (TRAb) antibodies were measured by using electrochemiluminescence immunoassay Kits. Data analysis was performed using the statistical package SPSS version 18.0 (SPSS, Inc). Results: The levels of serum BPA were significantly higher in the total YUICH group compared with that in the controls（0.85±0.15ng/L vs 0.535±0.11ng/L,P＜0.01). Significant difference was also observed in TPO -Ab and IGF-1 between YUICH patients and controls, (12±1.7 ng/L vs 6.7±2.7 IU/L and 65.2±10.4ng/L vs 105±9.5 ng/L, both of P ＜0.01). Similar trends were observed in the male and Female subgroup. Mean FT4 level was higher in male YUICH groups than in the control groups (45±10.2 nmol/L vs 26 ± 9.2 nmol/L,P＜0.01) ,and TSH was higher in female YUICH group than in the control (9±2.3 ng/Lvs2.1±0.4 ng/L, P＜0.01 ). Linear relation and regression analysis have shown that increasing serum BP-A level were statistically positively correlated with TPOA (r=0.47,P＜ 0.01),and significant negatively associated with low IGF-1 level (r = - 0.49, P＜0.01). additionally, Serum BP-A was positively related with serum free- thyroxine for male YUICH groups（r = 0.42, P＜0.01), but was negatively correlated with thyroid stimulating hormone for female YUICH group ( r= - 0.41, P ＜0.01). However, no statistical difference was noted for serum TgAb and TRAb. Conclusion: Our findings firstly demonstrated that BP-A exposure increased in YUICH patients compared with that in healthy controls. While Female is subclinical hypothyroidism and Male is hyperthyroidism ( high T4) and IGF-1 levels decreased. TPOAb presented a positive association with BP-A. It is concluded that hormone disorder induced by BP-A exposure might be an environmental factor in the pathology of YUICH. Funding Statement: Supports from the Natural Science Foundation of Shanxi provincial (2010011055-10; Shanxi Provincial Science and Technology Department of the Project Fund (2011099); Spark Planning Project of Changzhi City of Shanxin Provin (200704009). Declaration of Interests: The authors declare no conflict of interest. Ethics Approval Statement: All subjects gave their informed consent for inclusion before they participated in the study to be conducted in accordance with the declaration of Helsinki, and the protocol was approved by the Ethics Committee of the Affiliated Changzhi Municipal People's Hospital of Shanxi Medical University (Ethical code: No.2013093).