High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes.

Jer-Chuan Li,Hsin-Dean Chen,Du-An Wu,Yi-Maun Subeq,Jia-Sian Hou,Bang-Gee Hsu

doi:10.1155/2016/8380279

Abstract

Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels (P < 0.001) than those without MetS. Female DM persons had higher A-FABP level than man (P < 0.001). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (P < 0.001), logarithmically transformed creatinine (log-creatinine; P < 0.001), female DM patients (P < 0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; P = 0.013) were positively correlated, while albumin (P = 0.004) and glomerular filtration rate (GFR; P = 0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients.

Highlights

Metabolic syndrome (MetS) is a clustering of metabolic risk factors for atherosclerotic cardiovascular disease and diabetes mellitus (DM) [1]
Higher waist circumference (P < 0.001), body weight (P < 0.001), and Body mass index (BMI) (P < 0.001), higher fasting glucoses (P = 0.033), TG (P = 0.001), and lower high-density lipoprotein cholesterol (HDL-C) concentrations (P < 0.001) since MetS represents a constellation of hypertension, abdominal obesity, impaired fasting glucose, and dyslipidemia
Our study showed that fasting Adipocyte fatty acid binding protein (A-FABP) levels were higher in type 2 DM patents with MetS, and body fat mass, creatinine, female, albumin, high-sensitivity C-reactive protein (hs-CRP), and glomerular filtration rate (GFR) were independent predictors of serum A-FABP levels in type 2 DM patients

Summary

Introduction

Metabolic syndrome (MetS) is a clustering of metabolic risk factors for atherosclerotic cardiovascular disease and diabetes mellitus (DM) [1]. A-FABP has been shown to affect insulin sensitivity, lipid metabolism, and lipolysis in animal studies [3]. Studies found that AFABP is a key mediator for the obesity-related cardiovascular disease and is positively associated with MetS [3, 5]. Our previous studies noted that A-FABP was associated with MetS in coronary artery disease and in hemodialysis patients [6, 7]. The aim of this study was to investigate the relationship between fasting serum A-FABP level and the MetS among type 2 DM patients

Objectives

Results

Conclusion