Abstract
Background The relationship between high-sensitivity cardiac troponin T (hs-cTnT) and different cardiovascular events has been observed in several large community studies, and the results have been controversial. However, there is currently no cross-sectional or longitudinal follow-up study on hs-cTnT in the Chinese population. Methods We analyzed the association of plasma hs-cTnT levels with major adverse cardiovascular events (MACEs) and all-cause mortality in 1325 subjects from a longitudinal follow-up community-based population in Beijing, China. Results In the Cox proportional hazards models analysis, the risk of MACEs increased with the increase of hs-cTnT levels (HR, 1.223, 95% CI, 1.054–1.418, P=0.008). Increased hs-cTnT levels were associated with coronary events (HR, 1.391, 95% CI, 1.106–1.749, P=0.005) in Model 4. Cox proportional risk regression model analysis revealed that increased hs-cTnT levels were associated with an increased risk of mortality (HR, 1.763, 95% CI, 1.224–2.540, P=0.002), even after adjusting hs-CRP and NT-proBNP. The area under the ROC curve for predicting MACEs was 0.559 (95% CI, 0.523–0.595, P=0.001). The areas under the ROC curve for predicting coronary events and mortality were 0.629 (95% CI, 0.580–0.678, P < 0.001) and 0.644 (95% CI, 0.564–0.725, P < 0.001), respectively. Conclusions Our findings in the Chinese cohort support that hs-cTnT is a risk factor for major adverse cardiovascular events and all-cause mortality.
Highlights
It is extremely challenging to predict cardiovascular events in the general population; while the general population is unlikely to become a target of preventive measures, such measures have become a mainstay of how society addresses cardiovascular diseases [1]
Studies have found that the concentration of high-sensitivity cardiac troponin T (hs-cTnT) in patients with stable coronary heart disease is significantly related to cardiovascular death or Cardiology Research and Practice congestive heart failure [3, 4]
The average age was 59.10 ± 9.8 years, and 51.5% were females. Of these 1,325 people, 736 had a detectable level of hs-cTnT (>3.0 pg/ml), accounting for 55.54% of the total, as shown in Table 1. e distribution range of hs-cTnT was from 3.03 pg/ml to 176.4 pg/ml, and the median was 7.36 pg/ml (25% and 75% digits were 4.76 pg/ml and 15.58 pg/ml, respectively). ere were 143 people with an increased hs-cTnT (≥14.0 pg/ml), accounting for 10.79% of the total
Summary
It is extremely challenging to predict cardiovascular events in the general population; while the general population is unlikely to become a target of preventive measures, such measures have become a mainstay of how society addresses cardiovascular diseases [1]. Traditional risk factors such as hypertension, diabetes, hyperlipidemia, smoking, and obesity play important roles in the occurrence and development of cardiovascular disease. Studies have found that the concentration of hs-cTnT in patients with stable coronary heart disease is significantly related to cardiovascular death or Cardiology Research and Practice congestive heart failure [3, 4]. There is currently no cross-sectional or longitudinal followup study on hs-cTnT in the Chinese population
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