High-sensitivity C-reactive protein, Malondialdehyde and their association with Glycated hemoglobin (HbA1c)in type 2 diabetes patients

Abstract

Type 2 diabetes mellitus is a major public health problem worldwide and accompanied by enduring vascular complications, which leads to morbidity and mortality. Inflammation play major role in the pathogenesis of type 2 diabetes mellitus. High sensitivity C-reactive protein is an acute phase protein synthesized by the liver and has been revealed as sensitive, systemic inflammatory marker . Oxidative stress, low grade systemic inflammation contributes to insulin resistance and is linked to the characteristics of metabolic syndrome and type 2 diabetes mellitus. The present study was to evaluate hs - CRP, malondialdehyde (MDA) levels in type 2 diabetic patients compare with healthy controls and correlate these levels with glycated hemoglobin (HbA1C) and insulin resistance Fifty type 2 diabetic patients with age group of 35 to 45 years were selected for this study and 50 age matched healthy subjects were selected as controls. Ser um hs- CRP and insulin was assessed by ELISA, malondialdehyde (MDA) was assessed by Thiobarbituric Acid Reactive Substances (TBARS) method and other routine investigations were carried out by standardized protocols with ERBA EM-360 fully automated analyzer. The mean serum hs - CRP and MDA levels were significantly increa sed in type 2 diabetic patients com pared with healthy controls. Hs-CRP and MDA levels w ere shown significant positive correlation with glyc osylated hemoglobin (HbA1C), insulin resistance, triglycerides and negative correlation with HDL cholesterol. Elevated hs - CRP, MDA levels are potentially important diagnostic markers for the assessment of endothelial dysfunction in type 2 diabetic patients. Tight blood glucose control, regular monitoring of hs-CRP, MDA levels within normal range might be useful for reduction of vascular complications in type 2 diabetic patients.