High sensitive C- reactive protein and microalbumin in type 2 diabetes mellitus

Abstract

Background: Diabetes mellitus is one of the leading causes of m orbidity and mortality because of its role in the development of optic, renal, neuropathic and cardio vascular diseases (CVD). It is major public health care problem in developed countries as well as developing areas like India. Objectives: The aim of this study is to determine the serum high sensitive C- Reactive Protein (hs-CRP) a nd urinary microalbumin levels in patients with typ e 2 diabetes mellitus and to compare with healthy controls. Materials and Methods: In this study total 80 subjects were included above 40 years of age. 40 clinically diagn osed type 2 diabetic patients and 40 normal subject s were recruited as control. Microalbumin and hs-CRP were measured by latex turbidimetric method. Statistical Analysis: Data were analyzed using student ‘t’ test for their level of significance. Results: The mean microalbumin level in type 2 diabetic patients was significantly higher t han in the controls. The serum hs-CRP levels were s ignificantly higher in patients as compared to control subjects. Conclusion: Increased levels of hs-CRP and microalbumin may be implicated in the development of cardiovascular disease and renal impairment and these investigatio ns will defiantly help in the management of diabetic patien ts.