Abstract
This meta-analysis aims to explore the risk of colorectal polyps among non-alcoholic fatty liver disease (NAFLD) patients. We searched PubMed, EMBASE, and Cochrane library databases using predefined search term to identify eligible studies (published up to 7 November 2019). Data from selected studies were extracted by using a standardized information collection form, and meta-analyses were performed using random-effects model. The statistical heterogeneity among studies (I2 ), subgroup analyses, meta-regression analyses, and the possibility of publication bias were assessed. Twenty observational (12 cross-sectional, two case-control, and six cohort) studies met the eligibility criteria, involving 142387 asymptomatic adults. In cross-sectional/case-control studies, NAFLD was found to be associated with an increased risk of colorectal polyps (odds ratio [OR]=1.34; 95% confidence interval [CI]=1.23-1.47) (including unclassified colorectal polyps, hyperplastic polyps, adenomas, and cancers) with statistically significant heterogeneity (I2 =67.8%; P<0.001). NAFLD was also associated with a higher risk of incident colorectal polyps (hazard ratio=1.60; 95% CI=1.36-1.87) with low heterogeneity (I2 =21.8%; P=0.263) in longitudinal studies. The severity of NAFLD was associated with a higher risk of colorectal adenomas (OR=1.57; 95% CI=1.30-1.88), but not colorectal cancer (OR=1.37; 95% CI=0.92-2.03). The subgroup analysis according to gender showed that NAFLD was significantly associated with a higher risk of colorectal polyps in the male population without significant heterogeneity (OR=1.47; 95% CI=1.29-1.67, I2 =0%), but not in the female population (OR=0.88; 95% CI=0.60-1.29, I2 =34.2%). NAFLD was associated with an increased risk of colorectal polyps. There was a significant difference of the relationship between genders, which suggested more precise screening colonoscopy recommendation in NAFLD patients according to gender.
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