Abstract
By combining magnetic field cycling in the range from 0.1 mT to 7 T with high-resolution NMR detection the T 1 relaxation dispersion (nuclear magnetic relaxation dispersion (NMRD)) of protons in the nucleotides adenosine mono-phosphate and guanosine mono-phosphate was measured in a site-specific way. While at high field the individual spins have distinctly different T 1 times, their scalar spin–spin interaction fulfills at low field the condition of strong coupling and leads to convergence of their T 1 dispersion curves. In addition, the spin–spin coupling can lead to oscillatory components in the relaxation kinetics traceable to a coupling between spin polarization and coherence in the relaxation process. As a consequence the NMRD curves do not directly reflect the spectral density function of the motional processes, but the effects of motion and spin coupling must be separated for a reliable evaluation. A theoretical approach is described allowing such an analysis.
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