Abstract
A high-resolution second-harmonic optical coherence tomography (SH-OCT) system is demonstrated using a spectrum broadened femtosecond Ti:sapphire laser. An axial resolution of 4.2μm at the second-harmonic wave center wavelength of 400 nm has been achieved. Because the SH-OCT system uses the second-harmonic generation signals that strongly depend on the orientation, polarization, and local symmetry properties of chiral molecules, this technique provides unique contrast enhancement to conventional optical coherence tomography. The system is applied to image biological tissues of the rat-tail tendon. Highly organized collagen fibrils in the rat-tail tendon can be visualized in recorded images.
Highlights
Optical coherence tomographyOCTis an emerging imaging technology that provides in vivo high-resolution, cross-sectional images of biological tissues
Many cancers originate in the epithelium that has a thickness suitable for OCT imaging, but in their early stages when these cancers are developing through cell dysplasia, changes in tissue morphology and refractive index between normal and diseased tissues are very small and difficult to detect
We demonstrate a high-resolution secondharmonic optical coherence tomographySH-OCTsystem
Summary
Title High-resolution second-harmonic optical coherence tomography of collagen in rat-tail tendon High-resolution second-harmonic optical coherence tomography of collagen in rat-tail tendon
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