Abstract
Hereditary defects in amino acid metabolism are involved in several neurological disorders, 1,5,7,14,17,22 and the urinary excretion pattern has been shown to be a useful diagnostic aid. 9 Qualification of the amino acid content of a sample can best be done on an automatic analyzer. However, this technique requires 24 16 to 48 hours 19 for each assay for physiological fluids, with only one sample being examined at a time. This approach is unsuitable for the large-scale study of clinical populations. A screening procedure is necessary so that large numbers of patients can be routinely examined and those with a frankly normal distribution pattern eliminated without time-consuming quantitative analysis. Rapidity and small expense have encouraged the use of circular paper chromatography as a screening technique, 6 but this approach sacrifices resolution for speed. The group separation that is achieved is often inadequate. Thin-layer chromatography, 20 as a routine tool
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