Abstract
Monitoring intracorporal pressures are important for health care and diagnosis. In this work, a contact lens tonometer employing graphene woven fabrics (GWFs), which indicate great sensibility of resistance to strain, flexibility, stretchability, transparency, and biocompatibility, is proposed for real-time monitoring intraocular pressure (IOP) with high resolution. The mechanical properties of the device during the deformation were analyzed, and the sensitivity of the fabricated device was tested on a mimic human eyeball. In vitro experiments on porcine eyes were executed to test the effectiveness of the device. The change rate of resistance under different IOP was tested. Also, the relationship between the current changes and IOP variation when keeping the voltage constant for different devices was obtained. The contact lens tonometers with GWFs as high-resolution sensing element have shown a promising prospective to realize the low-cost disposable sensing contact lens with lower power.
Highlights
Human physiological index measurement has a significant role in biological research, medical detection, diagnosis, and therapy[1,2,3]
We focus on measurement of intraocular pressure (IOP), which is a major feature to characterize glaucoma, a leading course
The results show that using graphene woven fabrics (GWFs) as the sensitive element the device was more sensitive than the previously reported contact lens tonometers
Summary
Human physiological index measurement has a significant role in biological research, medical detection, diagnosis, and therapy[1,2,3]. Intracorporal pressures, such as endocardial pressure, intracapsular pressure, intraocular pressure (IOP), and intracranial pressure, are important phenotypes for health care and diagnosis. Miniaturized devices based on micro/nanotechnology enable real-time monitoring intracorporal pressures. We focus on measurement of IOP, which is a major feature to characterize glaucoma, a leading course of blindness[7]. The traditional devices, such as indentation tonometers and applanation tonometers, can be only performed in hospital and cannot monitor the IOP for a long time, which is necessary for some serious patients to be reminded for medical counter measure[7]
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