High-resolution NMR spectroscopy in inhomogeneous B0 and B1 fields by two-dimensional correlation

Abstract

Recently, there has been much interest in methods for obtaining high-resolution NMR spectra in inhomogeneous B 0 and B 1 fields and in their application to so-called ‘ex situ’ spectroscopy, where the sample and magnet/probe assembly are spatially separated. Here we discuss the implementation of the well-known two-dimensional nutation experiment as a method for correlating B 0 and B 1 inhomogeneities and, hence, achieving a high-resolution NMR spectrum. The advantages of this approach lie in its simplicity, its spatial (‘depth’) resolution, and in its not requiring a linear correlation of fields, i.e., B 1= αB 0+ k, across the sample.