Abstract
Considering the general application of dedicated small-animal positron emission tomography/computed tomography is limited, an acceptable alternative in many situations might be clinical PET/CT. To estimate the feasibility of using clinical PET/CT with [F-18]-fluoro-2-deoxy-D-glucose for high-resolution dynamic imaging and quantitative analysis of cancer xenografts in nude mice. Dynamic clinical PET/CT scans were performed on xenografts for 60 min after injection with [F-18]-fluoro-2-deoxy-D-glucose. Scans were reconstructed with or without SharpIR method in two phases. And mice were sacrificed to extracting major organs and tumors, using ex vivo γ-counting as a reference. Strikingly, we observed that the image quality and the correlation between the all quantitive data from clinical PET/CT and the ex vivo counting was better with the SharpIR reconstructions than without. Our data demonstrate that clinical PET/CT scanner with SharpIR reconstruction is a valuable tool for imaging small animals in preclinical cancer research, offering dynamic imaging parameters, good image quality and accurate data quatification.
Highlights
PET/CT is a powerful tool for tumor diagnosis, prognosis and relavent research in clinical
We observed that the image quality and the correlation between the all quantitive data from clinical PET/CT and the ex vivo counting was better with the SharpIR reconstructions than without
Our data demonstrate that clinical PET/CT scanner with SharpIR reconstruction is a valuable tool for imaging small animals in preclinical cancer research, offering dynamic imaging parameters, good image quality and accurate data quatification
Summary
PET/CT (positron emission computed tomography combination with X-computed tomography) is a powerful tool for tumor diagnosis, prognosis and relavent research in clinical. With specific radiotracers, it can reflect organs physiological, pathological, biochemical, metabolic and even tumor marker changes at the molecular level. Small-animal PET/CT scanners are constructed high-performing systems highly adapted to the morphology and physiology of small animals [3]. It plays an important role as a bridge between the mechanisms of basic disease research and clinical medical transformation
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