Abstract

AbstractProton MR Spectroscopy without water suppression has the advantage of the availability of intact water signal which can be used as an internal reference in quantitative analysis and for baseline correction. Moreover spectra obtained with this technique do not need phase correction. However, spectroscopy without water suppression is hampered by the sideband artifacts. These artifacts seriously complicates the quantitative analysis and therefore it is necessary to remove them.The aim of this study was to develop a method that will enable to reduce the influence of the sideband artifacts on the spectra and will gain all the advantages of spectroscopy without water suppression.Spectra from six healthy volunteers were acquired on 3T (TimTrio, Siemens, Erlangen, Germany) scanner with a PRESS sequence for volume selection. Postprocessing was performed in three steps: correcting the water peak position in all spectra (frequency correction), subtracting the Gaussian convolution of all FID’s (water signal reduction) and subtracting the FID of a water phantom from the volunteer’s FID signal (reduction of sidebands). For the postprocessing a customized software was developed with Matlab 2007b (MathWorks Inc. Natick, MA, USA).The described technique provides spectra with reduced water signal and sidebands. Moreover since all acquired spectra do not need phase correction, it is possible to calculate a mean spectrum from a few voxels which lies within the particular region of interest. With this averaging procedure an additional gain in Signal-to-Noise-Ratio (SNR) can be obtained.Keywordshi-res CSIwater suppressionaverage spectrumphase correctionsidebands

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