High-resolution (7-T) Liver MRI for Pathologic Examination.

Abstract

HomeRadiologyVol. 306, No. 1 PreviousNext Reviews and CommentaryFree AccessImages in RadiologyHigh-resolution (7-T) Liver MRI for Pathologic ExaminationJérémy Dana , Aïna VenkatasamyJérémy Dana , Aïna VenkatasamyAuthor AffiliationsFrom the Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg, Inserm, U1110, 3 Rue Koeberlé, 67000 Strasbourg, France (J.D.); Institut Hospitalo-Universitaire, Strasbourg, France (J.D., A.V.); Department of Diagnostic Radiology, McGill University Health Centre, Montreal, Canada (J.D.); Streinth Laboratory (Stress Response and Innovative Therapies), Inserm UMR_S 1113 IRFAC, Interface Recherche Fondamentale et Appliquée à la Cancérologie, Strasbourg, France (A.V.); and Department of Radiology–Medical Physics, University Hospital Freiburg, Freiburg, Germany (A.V.).Address correspondence to J.D. (email: [email protected]).Jérémy Dana Aïna VenkatasamyPublished Online:Sep 6 2022https://doi.org/10.1148/radiol.220410MoreSectionsPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In Online supplemental material is available for this article.Two different liver samples from patients who underwent surgical resection were imaged with a 7-T MRI scanner by using fat-suppressed fast spin-echo T2-weighted sequence, reaching spatial resolution of 75 × 75 × 200 μm in 2 hours.An MRI scan clearly demonstrated the homogeneous architecture of the normal liver (Figure) and identified the primary liver lobule, with its centrilobular vein and peripheral portal tracts (Figure, B and C) within the interlobular delineations (Figure, B). In stage 2 fibrotic liver (Fig E1 [online]), an MRI scan of the liver sample demonstrated correlation with pathologic findings, easily identifying the same fibrous portal bridges (Fig E1A and E1B [online]) and enlarged fibrous portal tracts (Fig E1A and E1B [online]), thus enabling a similar grading of fibrosis. With a spatial resolution close to that of the pathologic examination, MRI enabled an easier depiction of the liver lobule boundaries, allowing early detection of fibrosis-related architectural distortion. Additionally, the specimen remained intact, as no specific preparation was required for the MRI scan, and could undergo standard pathologic processing after image acquisition.Images show radiologic-pathologic correlation of normal liver. (A) Fat-suppressed T2-weighted MRI scan, with a spatial resolution of 75 × 75 × 200 μm, shows the homogeneous architecture of normal liver. (B) MRI scan (magnified image) depicts the anatomy of the primary liver lobule with its centrilobular vein (arrowhead) and peripheral portal venous tracts (arrow) within the interlobular delineations (star). (C) Mirrored pathologic slide, with Masson trichrome staining at four times magnification, identifies the liver lobule with the centrilobular vein (arrowhead) and peripheral portal tracts (arrow) within the interlobular delineations (black lines). (D) Schematic representation of the primary liver lobule with the centrilobular vein (central blue dot) and peripheral portal venous tracts (arrow).Download as PowerPointOpen in Image Viewer Disclosures of conflicts of interest: J.D. Research grant from the French Society of Radiology. A.V. Support from Bracco to attend RSNA 2021; faculty member for ESHNR.AcknowledgmentsWe thank Chrystelle Po, PhD (ICube UMR 7357, Université de Strasbourg/CNRS, Fédération de Médecine Translationnelle de Strasbourg, France), Antonin Fattori, MD (Département de Pathologie, Hôpitaux Universitaires de Strasbourg, France), Catherine Schuster, PhD (Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, Strasbourg, France), Thomas F. Baumert, MD, PhD (Université de Strasbourg, Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, Strasbourg, France), Benoit Gallix, MD, PhD (Institut Hospitalo-Universitaire, Strasbourg, France), and Pr Patrick Pessaux, MD, PhD (Département de Chirurgie Viscérale et Digestive, Pôle Hépato-digestif, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France) for their crucial contribution. Supported by French state funds managed within the "Plan Investissements d’Avenir" and by the ANR (ANR-10-IAHU-02 to B.G.), the ARC, Paris and Institut Hospitalo-Universitaire, Strasbourg (TheraHCC 2.0 and IHUARC2019 to T.F.B.), the European Union (ERC-AdG-2014-671231-HEPCIR and ERC-AdG-2020-667273-FIBCAN to T.F.B.), ANRS, Paris (ECTZ160436 and ECTZ103701 to T.F.B), the Foundation of the University of Strasbourg (HEPKIN to T.F.B.), and the Institut Universitaire de France (T.F.B.). This work has been published under the framework of the LABEX ANR-10-LABX-0028_HEPSYS and Inserm Plan Cancer.Article HistoryReceived: Feb 23 2022Revision requested: Mar 22 2022Revision received: Apr 9 2022Accepted: Apr 25 2022Published online: Sept 06 2022Published in print: Jan 2023 FiguresReferencesRelatedDetailsRecommended Articles A Comprehensive Approach to Hepatic Vascular DiseaseRadioGraphics2017Volume: 37Issue: 3pp. 813-836Imaging Findings of Congestive HepatopathyRadioGraphics2016Volume: 36Issue: 4pp. 1024-1037Noninvasive Staging of Liver Fibrosis Using 5-Minute Delayed Dual-Energy CT: Comparison with US Elastography and Correlation with Histologic FindingsRadiology2021Volume: 298Issue: 3pp. 600-608Catheter-directed Intraportal Delivery of Endothelial Cell Therapy for Liver Regeneration: A Feasibility Study in a Large-Animal Model of CirrhosisRadiology2017Volume: 285Issue: 1pp. 114-123Pulmonary Functional Imaging: Part 1—State-of-the-Art Technical and Physiologic UnderpinningsRadiology2021Volume: 299Issue: 3pp. 508-523See More RSNA Education Exhibits Radiological-Pathological Correlation in Diffuse Lung Diseases Using Ultra-High-Resolution Computed Tomography (U-HRCT): From Miller’s to Reid’s LobuleDigital Posters2019Peribronchovascular Disease on CT: Diagnostic Approach and Imaging FindingsDigital Posters2020Imaging of Hepatic Periportal Lesions and Perivenous LesionsDigital Posters2018 RSNA Case Collection Arterioportal fistulaRSNA Case Collection2021Hepatic AngiosarcomaRSNA Case Collection2021Perihilar Cholangiocarcinoma RSNA Case Collection2021 Vol. 306, No. 1 Supplemental MaterialMetrics Altmetric Score PDF download