Abstract
Optical Computed Tomography (CT) is a promising technique for dosimetry of Microbeam Radiation Therapy (MRT), providing high resolution 3D dose maps. Here different MRT irradiation geometries are visualised showing the potential of Optical CT as a tool for future MRT trials. The Peak-to-Valley dose ratio (PVDR) is calculated to be 7 at a depth of 3mm in the radiochromic dosimeter PRESAGE®. This is significantly lower than predicted values and possible reasons for this are discussed.
Highlights
Microbeam Radiation Therapy (MRT) is a new therapy that makes use of the fact that spatially fractionated dose is very well tolerated by normal tissue while being lethal to tumours [1]
The cuvette optical density measurements verified the linear response of PRESAGE® to dose and the Optical Computed Tomography (CT) system’s dose response was found to be linear up to a dose of 100Gy
Visualisation Different MRT irradiation geometries were visualised with some results shown in figure 1
Summary
Microbeam Radiation Therapy (MRT) is a new therapy that makes use of the fact that spatially fractionated dose is very well tolerated by normal tissue while being lethal to tumours [1]. Treatments involve delivering dose in narrow, well collimated x-ray beams the order of 50μm wide. Dosimetry of this therapy is challenging as there is no commercially available technique that can deliver the high resolution and high dynamic range measurements required [2]. Using a 3D dosimeter it is possible to provide ‘end-to-end’ quality assurance of the entire therapy process, including planning Computed Tomography (CT) scans and Treatment Planning calculations. Optical CT has been previously shown to be a potential candidate to fill this gap [4]. This type of dosimetry would be complementary to existing ultra-high resolution planar techniques
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