Abstract
High-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-diabetic compounds in Eremanthus crotonoides (Asteraceae)
Highlights
Type 2 diabetes (T2D) is a chronic metabolic disorder that constitutes a global health problem, being responsible for almost 90% of all cases of diabetes in adults [1]
Severe micro- and macrovascular complications in T2D are caused by postprandial hyperglycemia following α-glucosidase-catalyzed hydrolysis of dietary carbohydrates—but the hydrolysis and absorption of glucose can be reduced by α-glucosidase inhibitors [4,5]
The very recent development of state-of-the-art high-resolution bioassays combined with hyphenation of high-performance liquid chromatography, high-resolution mass spectrometry, solid-phase extraction and nuclear magnetic resonance spectroscopy [8], i.e., HR-bioassay/HPLC-HRMS-SPE-NMR has been an important tool for identification of α-glucosidase
Summary
Type 2 diabetes (T2D) is a chronic metabolic disorder that constitutes a global health problem, being responsible for almost 90% of all cases of diabetes in adults [1]. Severe micro- and macrovascular complications in T2D are caused by postprandial hyperglycemia following α-glucosidase-catalyzed hydrolysis of dietary carbohydrates—but the hydrolysis and absorption of glucose can be reduced by α-glucosidase inhibitors [4,5]. Several side effects have been reported [6,7], which makes the search for new α-glucosidase inhibitors of utmost importance. From this perspective, the very recent development of state-of-the-art high-resolution bioassays combined with hyphenation of high-performance liquid chromatography, high-resolution mass spectrometry, solid-phase extraction and nuclear magnetic resonance spectroscopy [8], i.e., HR-bioassay/HPLC-HRMS-SPE-NMR has been an important tool for identification of α-glucosidase
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