Abstract
AbstractThe α‐regioselectivity of carbonyl crotylation is a long‐standing problem in the realm of C–C bond formation reactions. We demonstrate that zinc‐mediated crotylation of aldehydes and ketones can afford α‐linear homoallylic alcohols exclusively to provide a simple solution for this problem. In this context, we describe a method for the α‐regioselective crotylation of aldehydes and ketones by using an easily available starting material, such as crotyl bromide, zinc dust, and the less‐toxic solvent DMPU. The reaction has broad substrate scope and is highly efficient. Moreover, a metallo‐[3,5]‐sigmatropic rearrangement is proposed to account for the high α‐regioselectivity in the zinc‐mediated crotylation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
