Abstract
The budding yeast Saccharomyces cerevisiae is a safe and widely used host for the production of heterologous proteins. Nowadays, interesting perspectives from r-DNA applications also arise from the opportunity to modify metabolic pathways, yielding engineering yeast cells useful for chemicals production. In this paper we describe yeast strains that express the bovine muscle lactic dehydrogenase gene (LDH-A). These strains allow to carry out lactic acid fermentations with both high production (20 gl−1) and high productivity (11 g l−1 h−1) of lactic acid.
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