High Prevalence of SARS-CoV-2 in an Indigenous Community of the Colombian Amazon Region.

Héctor Serrano-Coll,Wilkhen Novoa,Misael Oviedo,Bertha Gastelbondo,Salim Mattar,Camila Rodríguez-Van Der Hamen,Hollman Miller,Ricardo Rivero,Evelin Garay

doi:10.3390/tropicalmed6040191

Abstract

Introduction. COVID-19 is a pathology caused by the SARS-CoV-2 virus. The World Health Organization (WHO) has reported more than 225 million cases and 4.5 million deaths worldwide. Objective: To describe the seropositivity, spatial distribution, and clinical and sociodemographic variables of SARS-CoV-2 in a community of the Colombian Amazon region. Methods. In December 2020, a cross-sectional observational study was carried out in a population located in the Colombian Amazon in the municipality of Mitú. Sociodemographic and clinical data were taken. Besides, 589 blood samples were taken, and an antibody detection was carried out with an ELISA and a recombinant protein N antigen of SARS-CoV-2. Results. A seropositivity of 57.6% was observed. The highest proportion of the infection is located in inter-municipal transport zones. The bivariate analysis did not show differences in the SARS-CoV-2 infection rate concerning the variables sex, age range, and the presence of comorbidities (p > 0.05). The bivariate and multivariate analysis showed that being symptomatic and presenting neurological manifestations of the upper respiratory tract are clinical variables associated with SARS-CoV-2 infection (p < 0.05). One of the causes of this virus’s high spread in this community could be that 53.3% of the people were asymptomatic. Conclusions. Our data showed a high burden and transmission of SARS-CoV-2 in the indigenous community. This could be linked to cultural behaviors and the high infection rate in asymptomatic patients.

Highlights

Introduction iationsThe World Health Organization (WHO) has reported more than 225 million cases and4.5 million deaths related to COVID-19 in the world [1]
The seropositivity against SARS-CoV-2 evidenced in this area of the Colombian Amazon was 57.6% and could be considered within the serological studies as one of the world’s highest
Our findings exceed those found in the principal city of the Brazilian Amazon, Manaus, where 44% community seropositivity was reported [7], and in Atahualpa

Summary

Objective

Spatial distribution, and clinical and sociodemographic variables of SARS-CoV-2 in a community of the Colombian Amazon region. Our data showed a high burden and transmission of SARS-CoV-2 in the indigenous community. This could be linked to cultural behaviors and the high infection rate in asymptomatic patients. Proportion of asymptomatic individuals that would facilitate the spread of SARS-CoV-2 It is unknown in Colombia and neighboring countries, such as Brazil, Peru, and Venezuela, the behavior and spread of this virus in indigenous communities. This work’s objective was to describe the seropositivity, spatial distribution, and clinical and sociodemographic variables related to SARS-CoV-2 infection in a population of indigenous ancestry from the municipality of Mitú, Vaupés, Colombian Amazon

Methods

Results

Discussion