Abstract
ABSTRACT The extensive use of antimicrobial agents has contributed to the emergence of antimicrobial resistance and multidrug resistance (MDR) in Salmonella, an important zoonotic pathogen that causes outbreaks and sporadic cases of gastroenteritis in humans. The study aimed to investigate the antimicrobial resistance profile of Salmonella strains isolated from poultry in Brazil. A total of 230 Salmonella strains, isolated from cloacal swabs (n=56) and broiler carcasses swabs (n=174) before and after chilling from slaughterhouses under Federal Inspection Service within the period 2012-2017, were analyzed. Serotyping and antibiotic susceptibility testing were performed on all the isolates. Serotyping results showed that 41% of the strains were Salmonella Heidelberg, 29% S. Minnesota, 12% S. Saintpaul, 6.5% S. Enteritidis, 3.9% S. Anatum, 2.2% S. Cerro, 2.2% S. Senftenberg, 1.7% S. Newport, 0.4% S. Ealing, 0.4% S. O:4,5 and 0.4% S. O:9,12. MDR rates of the isolates were 67.4%. S. Heidelberg 89.5%, S. Minnesota 51.5%, S. Saintpaul 82.1%, S. Anatum 66.7%, S. Cerro 60%, S. Senftenberg 40%. Out of the 230 strains, 41.3% presented resistance to Penicillins + beta-lactamase inhibitor, Penicillin, 1st and 2nd Generation Cephalosporin, 3rd and 4th Generation Cephalosporin, Tetracycline and Sulfonamide. Salmonella Heidelberg, S. Saintpaul, S. Anatum, S. Cerro, S. Senftenberg and S. Minnesota were isolated after chilling tank highlighting a food safety concern for the industry of poultry and poultry products indicating a risk to collective health. The high prevalence of MDR nontyphoidal Salmonella obtained in this study limit the options available to treat infectious disease in humans and animals.
Highlights
Surveillance of antimicrobial resistance (AMR) can be very valuable for orienting treatment choices, understanding AMR trends, identifying priority zones for interventions and monitor the impact of interventions in order to contain resistance spread
According to “The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2017”, 91,662 human salmonellosis cases were reported in the European Union and it was identified in 1.241 (24.4%) foodborne outbreaks (FBO), affecting 9.600 people (EFSA; European Centre for Disease Prevention and Control (ECDC), 2018)
The aim of this study was to characterize the phenotypic profile of antimicrobial resistance and establish multidrug resistance (MDR) patterns of Salmonella strains isolated from broiler chickens and carcasses obtained from slaughterhouses in Brazil
Summary
Surveillance of antimicrobial resistance (AMR) can be very valuable for orienting treatment choices, understanding AMR trends, identifying priority zones for interventions and monitor the impact of interventions in order to contain resistance spread. Due to the overuse of antibiotics in animals and humans, the number of foodborne multidrug resistant Salmonella isolates has increased rapidly in the last years. These multidrug resistant strains cause a heavy burden on clinical diagnosis and treatment of salmonellosis and have become a major public health issue in Brazil and in several other countries (Zishiri et al, 2016; Xu et al, 2019). According to “The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2017”, 91,662 human salmonellosis cases were reported in the European Union and it was identified in 1.241 (24.4%) foodborne outbreaks (FBO), affecting 9.600 people (EFSA; ECDC, 2018)
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