Abstract
BackgroundElevated pretreatment lactate dehydrogenase (LDH) has been associated with poor prognosis in various malignancies; however, its prognostic role in hypopharyngeal cancer remains elusive. In this study, we aimed to assess the association between pretreatment LDH and clinical outcome of hypopharyngeal cancer.MethodsWe retrospectively collected 198 hypopharyngeal cancer patients treated with surgery in our institution between 2004 and 2018. The prognostic role of pretreatment LDH was explored by using univariate and multivariate analyses. Besides, subgroup analysis was performed based on T stage.ResultsThree-year and Five-year of disease-free survival (DFS, 67.0 vs. 57.4%, 65.8 vs. 39.8%, p = 0.007) and overall survival (OS, 74.8 vs. 68.9%, 66.8 vs. 50.8%, p = 0.006) exhibited significant differences between low LDH level and high LDH level groups. Univariate analysis showed that pretreatment elevated serum LDH served as an unfavorable determinant with regard to DFS and OS. Further multivariate analysis also confirmed that LDH was an independent predictor for DFS and OS. Additionally, N status and age were also found to be significantly associated with both DFS and OS.ConclusionPretreatment elevated serum LDH is an inferior prognostic factor for patients with hypopharyngeal cancer. These results should be validated by more multicenter and prospective studies.
Highlights
Among head and neck squamous cell carcinomas, hypopharyngeal cancer is comparatively uncommon and aggressive [1]
Hypopharyngeal cancer occurs predominantly in males [2] with heavy alcohol consumption and tobacco use [3]. It is mainly arising from pyriform sinus, and early symptoms of this malignancy are often neglected, which contributes to the fact that hypopharyngeal cancer patients usually present with an advanced stage at their first diagnosis [4, 5]
We retrospectively reviewed patients diagnosed with hypopharyngeal cancer between March 2004 and December 2018 in our institution (Sun Yat-Sen Memorial hospital)
Summary
Among head and neck squamous cell carcinomas, hypopharyngeal cancer is comparatively uncommon and aggressive [1]. Hypopharyngeal cancer occurs predominantly in males [2] with heavy alcohol consumption and tobacco use [3]. The surgery modality for locally advanced hypopharyngeal cancer is pharyngectomy with total or partial laryngectomy, in conjunction with selective or radical neck dissection, with reasonable adjuvant treatment based on the presence of clinical adverse pathologic features [15]. Given the poor prognosis of advanced hypopharyngeal cancer, a novel prognostic determinant that can accurately predict clinical outcomes for these patients is urgently needed. Elevated pretreatment lactate dehydrogenase (LDH) has been associated with poor prognosis in various malignancies; its prognostic role in hypopharyngeal cancer remains elusive. We aimed to assess the association between pretreatment LDH and clinical outcome of hypopharyngeal cancer
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