Abstract
Summary A procedure for the rapid determination of pethidine in plasma is described. It involves a preliminary separation by solvent extraction and the separation of pethidine on a silica gel column at 2070 kPa. The mobile phase is hexane-ethanol-acetonitrile (65: 30: 5) and the wavelength of determination is 230 nm. 0.08% codeine phosphate in ethanol is used as an internal standard and the peak height ratio of drug to internal standard is used for drawing the calibration curve and measuring the concentration of the drug in the spiked plasma samples.
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