Abstract
BackgroundThe health benefits of omega-3 fatty acids from fish are well known, and fish oil supplements are used widely in a preventive manner to compensate the low intake in the general population. The aim of this open-label study was to determine if consumption of a high potency fish oil supplement could improve blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and impact SF-12 mental and physical health scores in healthy adults.MethodsA novel virtual clinical research organization was used along with the HS-Omega-3 Index, a measure of EPA and DHA in red blood cell membranes expressed as a percentage of total fatty acids that has been shown to correlate with a reduction in cardiovascular and other risk factors. Briefly, adult subjects (mean age 44 years) were recruited from among U.S. health food store employees and supplemented with 1.1 g/d of omega-3 from fish oil (756 mg EPA, 228 mg DHA, Minami Nutrition® MorEPA® Platinum) for 120 days (n = 157).ResultsOmega-3 status and mental health scores increased with supplementation (p < 0.001), while physical health scores remained unchanged.ConclusionsThe use of a virtual, web-based platform shows considerable potential for engaging in clinical research with normal, healthy subjects. A high potency fish oil supplement may further improve omega-3 status in a healthy population regularly consuming an omega-3 supplement.
Highlights
Considerable evidence has demonstrated that increasing consumption of omega-3 fatty acids can benefit health, most notably by reducing cardiovascular disease and its associated risk factors [1,2,3,4,5]
The American Heart Association recommends an intake of 1 g/d of combined eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from food or supplements for secondary prevention [20], and concentrated formulations of EPA and DHA are available as both dietary supplements and medications
The aims of the present study were to investigate the utilization of a new web-based program known as a virtual clinical research organization (CRO) and to assess the effects of a high potency fish oil on omega-3 status, as well as mental and physical health scores, in healthy adults who regularly consume an omega-3 supplement
Summary
Considerable evidence has demonstrated that increasing consumption of omega-3 fatty acids can benefit health, most notably by reducing cardiovascular disease and its associated risk factors [1,2,3,4,5]. Despite the clear need for more controlled studies in specific populations and targeting specific clinical outcomes, increasing blood EPA and DHA levels appears to have a generally positive impact on health, and awareness among the general population is high [18]. The health benefits of omega-3 fatty acids from fish are well known, and fish oil supplements are used widely in a preventive manner to compensate the low intake in the general population. The aim of this openlabel study was to determine if consumption of a high potency fish oil supplement could improve blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and impact SF-12 mental and physical health scores in healthy adults
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