Abstract
Plasma fibronectin (PFN) was studied in 63 children and adolescents with type I diabetes and in 25 healthy controls. All subjects included in the study were without signs of microangiopathic disease: no retinal lesions were demonstrable, plasma creatinine levels were lower than 1.0 mg/dl, and no proteinuria was demonstrable. The diabetic subjects were grouped according to their HbA1 values, the urinary sugar excretion, and the duration of clinical diabetes. PFN of the diabetic subjects was significantly higher than those of normal controls. The group with high HbA1 values had significantly higher PFN than the group with low HbA1 values. The group with high urinary sugar excretion had higher PFN values than the group with low urinary sugar excretion. PFN did not differ in the group with short or long duration of clinical diabetes. Our results show that in diabetic children and adolsecents without diabetic vascular disease but poor control of diabetes increased PFN can be demonstrated. An elevation of PFN might have some significance in the pathogenesis or propagation of diabetic vascular disease.
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