Abstract
Abstract A sensitive method involving the combined use of reversed-phase high-performance liquid chromatography and electrochemical detection has been developed for monitoring the formation of 8-oxo-7,8-dihydroadenine and 8-oxo-7,8-dihydro-2′-deoxyadenosine. The limit of detection for both compounds is close to 0.2 ng under optimised conditions of detection at an oxidation potential of 850 mV. This assay allows the quantitative measurement of the hydroxylated purine components in aqueous solutions of adenine and 2′-deoxyadenosine exposed to a dose of ionizing radiation as low as 2 Gray (Gy).
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
