Abstract
Aims: This research is focused on the in vitro evaluation of Cistus salviifolius L. antimicrobial properties and the determination of the contents of phenols and flavonoids.
 Study Design: This research is analytical study aimed to illustrate the antimicrobial properties and to analyze the methanolic extract contents of aerial parts of Cistus salviifolius L. by high-performance liquid chromatography techniques.
 Duration: The study was performed within six months in the Faculty of Pharmacy, Benghazy University.
 Methodology: Antimicrobial properties was tested against twelve organisms using Kirby-Bauer disk diffusion sensitivity test and the determination of the contents of phenols and flavonoids was evaluated by running high-performance liquid chromatography techniques.
 Results: The findings indicated that catechin is the most abundant flavonoid in C. salviifolius, while gallic acid was the major phenol in the methanolic extract of the plant. The results also revealed that the methanol extracts had a significant antimicrobial potential particularly against Bacillus subtilis and Escherichia coli with MIC (0.98 and 0.49) µg/ml respectively, furthermore the extract was effective against Aspergillus fumigatus with MIC 0.98 µg/ml. 
 Conclusion: C. salviifolius was highly rich with flavonoids and phenols and has a significant antimicrobial effect.
Highlights
Medicinal herbs have been regularly considered as a valuable source for the screening of bioactive compounds to treat various medical conditions [1]
This research aims to characterize the antimicrobial properties and to determine the contents of essential active compounds, polyphenols, and flavonoids by running highperformance liquid chromatography techniques to analyze the methanolic extract of aerial parts of Cistus salviifolius L
The present study was performed to assess the content of phenolic acids and flavonoids in the methanolic extract of the aerial parts of C. salviifolius L. using HPLC/UV according to the International Organization for Standardization by applying the method of Mattila et al [34]
Summary
Medicinal herbs have been regularly considered as a valuable source for the screening of bioactive compounds to treat various medical conditions [1]. Cistus is an evergreen genus of flowering shrubs that belongs to the Cistaceae, which comprises 8 genera and 180 species [4,5,6] This family is known with the common name RockRose [7], Cistaceae reveals the largest diversity in the floristic area of the Mediterranean [6]. For centuries the value of Cistus herbs was documented, the leaves of numerous species contain a brown aromatic sticky resin called labdanum. This type of resin has been routinely used for the management of coughs, colds, rheumatism, diarrhea, and menstrual problems, it is employed in the production of perfumes [9]. This research aims to characterize the antimicrobial properties and to determine the contents of essential active compounds, polyphenols, and flavonoids by running highperformance liquid chromatography techniques to analyze the methanolic extract of aerial parts of Cistus salviifolius L
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