Abstract
Abstract The pharmacological activity of seven β-blockers was evaluated based on retention time on high performance liquid chromatographv with an internal surface reversed-phase silica column (Pinkcrton column). Significant relationships were found between the adjusted retention times for β-blockers and their pharmacological effects, such as affinity for the β1 heart receptors (r = -0.714) and the β2 lung receptors (r = -0.937). Thus retention time on high performance liquid chromatography may be a rapid and replicable approach to the prediction of pharmacological effects.
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