Abstract
AbstractRamipril and its precursor I enantiomers (all-S and all-R optical isomers) were identified by liquid chromatographic method using Chiralcel stationary phase OT(+) column, after derivatization of proline residue with trifloroacetic anhydride to form trifloroacetamide. Maxium resolution (R) of 1.06 was obtained for precursor I enantiomers when chromatogramed as mixture. applied for optical purity determination of these precursors which are used for ramipril synthesis and also their detection as impurities in rarmpril.
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