Abstract
Two kinds of chiral 2,3-dimorpholinoquinoxalines bearing L-proline and N-bromoacetylproline residues at C-6 position were newly synthesized. The derivatization of (′)-naproxen, (′)-ibuprofen, and (′)-2-phenylpropionic acid with chiral quinoxalines afforded the diastereomers, which emitted an intense fluorescence. All the diastereomers were clearly separated within 16 min on reversed-phase (Finepak SIL C 1 8 S) HPLC equipped with a fluorescence detector. The detection limit of the derivatized product was estimated to be 5 pmol/10μL injection volume at S/N=5. Further, the quantum yield of the diastereomer was estimated to be 0.052 by using the relative quantum yield measurement with anthracene as a standard.
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