Abstract
High-performance liquid chromatographic determinations of gabexate mesilate (FOY) prostaglandin E 1 (PGE 1, PGE 1-α-cyclodextrin (PGE 1,-CD), prednisolone (PD) and butyl flufenamate (BF) incorporated in gel ointment were investigated. The gel ointment is composed of a carboxy vinyl polymer (1.3%, w/w) and a large amount of an aqueous organic solvent. A methanol extraction system offered simultaneous advantages of the removal of the polymer and the recovery of active ingredients from the gel phase. The recoveries of the drugs were 100%. The stabilities of PGE 1, PGE 1-CD, FOY, PD and BF incorporated in gel ointment, stored at 5, 25 and 40°C for up to 90 days, were investigated.
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