Abstract
Abstract The effect of tertiary butyl ammonium phosphate as a competing base has been investigated in the reverse phase separation of twenty-two sulphonamides (SFA) and three commonly used dihydrofolate reductase inhibitors (DHFR). At the concentrations of t-butyl ammonium phosphate examined, the retention of the DHFR was dramatically reduced, but did not aid the separation. The effects on the SFA were inconsistent with the known pKa, l data and suggested either more complex mechanisms of interaction with the stationary phase or some doubt regarding the pKa, l values.
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