Abstract
A rapid, selective, and simple high-performance liquid chromatographic assay for digitoxin formulations is described. The method utilizes a conventional octadecyl-bonded phase column with detection at 220nm. The isocratic solvent system resolves digitoxin from its potential degradation products and provides an accurate assay for tablet and injectable formulations with a relative standard deviation of 1.4 and 3.3%, respectively. The method is sufficiently sensitive to monitor content uniformity of tablets and the minimum quantifiable amount of digitoxin was determined to be 20ng. The total chromatograph time was ~15min.
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