Abstract
The separation of enantiomers of 3-fluoroalanine, 3,3-difluoroalanine and 3,3,3-trifluoroalanine on ChiralProCu, ChiralValCu and Chiral-1 Nucleosil columns was studied. The substitution of hydrogen for fluorine atoms results in a significant increase in the selectivity of separation of the enantiomers. The relationship between the number of fluorine atoms and the retention of enantiomers on different columns was studied. Optimum conditions for the separation of enantiomers were found.
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