High-pass filtering of carotid-vagal influences on expiration in rat: role of N-methyl- d-aspartate receptors

Abstract

Repetitive electrical stimulation of the carotid sinus nerve or vagus nerve in rats elicited abrupt reflex shortening or prolongation, respectively, of the inter-burst interval of phrenic nerve activity followed by exponential decay from the initial response. Removal of the stimuli resulted in transient post-stimulus rebound excitation or inhibition that mirrored the corresponding stimulus-evoked responses. The biphasic responses to these complementary inputs approximate the on- and off-transients of full-wave differentiators or high-pass filters. Blockade of N-methyl- d-aspartate (NMDA) receptors abolished the post-stimulus rebounds and transformed both signal pathways into integrators or low-pass filters, thus switching off part or all of the high-pass filters. We suggest that such NMDA receptor-dependent high-pass filtering effects may serve to increase the dynamic range and response speed of sensory neurotransmission to the brain, thereby enhancing closed-loop stability of sensorimotor reflex.