Abstract
s / Can J Diabetes 37 (2013) S13eS84 S64 low fat (LF; 10%) diets. Newborn pup hearts were analyzed for cardiac hypertrophy. The remaining offspring were weaned at 3 weeks of age and randomly assigned to LF or HFS diets for a period of 12 weeks. Results: Consumption of HFS diets by pregnant rats caused elevated gestational weight gain and mid-gestational hyperglycemia. The heart weight and heart weight:body weight ratio was 1.3-fold (p<0.01) greater in newborn neonates from GDM mothers. The postnatal consumption of HFS diets by offspring from GDM mothers increased the postnatal heart weight:tibia length ratio 1.3-fold (p<0.05) compared to offspring from lean mothers. Conclusion: GDM increases the susceptibility of rat offspring to cardiac hypertrophy. These findings have important implications since GDMmay be an important factor that contributes to the early onset of diabetic cardiomyopathy.
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