Abstract
Occlusion of renal artery during stenting procedure by endovascular aortic repair leads to ischemic-reperfusion injury (IRI). Additionally, significant amount of intravenous contrast agent is used during the procedure. Therefore acute kidney injury (AKI) is one of the most common postoperative complications. Current experimental data suggest an important role of systemic immune reaction in development of AKI after IRI and nephrotoxic agents. However, robust analysis of cellular immune response in clinical setting and its relation to AKI after IRI and iv contrast have not been previously reported.
Highlights
Occlusion of renal artery during stenting procedure by endovascular aortic repair leads to ischemic-reperfusion injury (IRI)
High normal values of circulating immune cell subsets before surgery may be protective against development of postoperative acute kidney injury
We evaluated the perioperative risk factors for acute kidney injury (AKI) after elective aortic surgery
Summary
Occlusion of renal artery during stenting procedure by endovascular aortic repair leads to ischemic-reperfusion injury (IRI). Significant amount of intravenous contrast agent is used during the procedure. Acute kidney injury (AKI) is one of the most common postoperative complications. Current experimental data suggest an important role of systemic immune reaction in development of AKI after IRI and nephrotoxic agents. Robust analysis of cellular immune response in clinical setting and its relation to AKI after IRI and iv contrast have not been previously reported
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